Transport Secretary Patrick McLoughlin will announce today that Birmingham has secured the new project base, shifting jobs from London to Birmingham.
He will also reveal that a £130m scheme to take the Midland Metro to Adderley Street, in Eastside, has been given the green light.
The HS2 Birmingham base will be in charge of building the track, stations and signalling as well as managing the staff needed to support their work.
Once the headquarters opens in 2015 it will represents the largest public sector relocation to Birmingham there has ever been.
The City Council also today announced it will create an urban regeneration company to lead the redevelopment around the planned Curzon Street HS2 station.
Curzon Street will become the Birmingham hub for HS2
In February, the council first announced plans to regenerate the Curzon Street area by building offices, a hotel and 2,000 homes.
McLoughlin said: “HS2 is a vital part of our long-term economic plan. By locating the new HS2 engineering HQ in Birmingham, we are bringing skilled job opportunities into the area, spreading HS2’s benefits beyond those using the new rail line.
“It is great news that Birmingham City Council has created a company specifically to focus on the regeneration opportunities created by HS2. It will bring new investment and work into the city, helping secure the future prosperity of the region and the country.”
The Greater Birmingham and Solihull Local Enterprise Partnership said it would be investing £30m to support plans for the 141 hectare site.
Earlier this month, the LEP was awarded more than £350m over three years through the government’s Growth Deal.
Funding was also earmarked for a new construction training centre in Dudley, as well as facilities at Birmingham’s South and City College, to help equip local people for jobs connected with the building of HS2.