The new dual carriageway will provide a new high-capacity route into Wigan town centre from the south of the borough
The proposed A49 Goose Green to Westwood Park Link Road project includes three major structures to bridge existing watercourses, canals and a primary road.
The upgrade scheme will improve two junctions along the A49 and pave the way for housing projects at Pemberton Park and Wigan Arc.
Firms have until 24 November to complete PQQs and can obtain more information from the Chest website.