The successful partners will be used to deliver individual projects worth more than £12m over four years.
Initially three national frameworks are planned covering project manager, cost advisers and supply chain partners.
Each supply chain partner must involve a constructor, two architects, two civil and structural engineers and building service engineers as well as a pair of electrical and mechanical contractors.
Interested firms must register on the eTenderwales portal by 2 December, with bids due to be invited from shortlisted firms next April.
Bam Construct, Balfour Beatty and Interserve were successful in gaining places on the Welsh Government’s ‘Designed for Life: Building for Wales 3’ National Framework four years ago.