The Temple Quarter Campus will be built near Bristol Temple Meads train station on the derelict former sorting office site.
The new campus scheme will include a Digital Innovation Hub, a ‘business school of the future’, student village and an enterprise hub known as the Engine Shed 2.
It’s hoped the campus will open in time for the start of the 2021/22 academic year.
The Temple Quarter Campus is the result of collaboration between the University, Bristol City Council, Government, industry and philanthropic investors.
Business and Energy Secretary Greg Clark said: “Our forthcoming Industrial Strategy is committed to creating highly skilled and versatile workforces in all areas of the UK.
“The development of this exceptional new campus for the University of Bristol is a brilliant example of this strategy in action, with government, academia and industry collaborating to deliver future-focused training that will build on Bristol’s growing reputation as a digital and tech cluster.”
Professor Hugh Brady, Vice-Chancellor and President of the University of Bristol, said: “This is an historic moment for the University of Bristol and for the city-region.
“This new initiative is, I believe, truly unique: a dynamic partnership between the University, industry and the city, located in an enterprise zone and major transport hub and offering the opportunity to position Bristol as a global leader in digital and educational innovation.”
Marvin Rees, Mayor of Bristol said: “The deal also gives us renewed hope of a solution to the eyesore of the former Sorting Office. In future, visitors will no longer be welcomed to Bristol by a derelict building, but by a flourishing and inclusive home of digital excellence, innovation, education and industry.”