This second phase will consist of four separate buildings of up to 10 storeys delivering 546 flats.
Designed by architect, WCEC Group, the scheme will be developed around three large basins of the Manchester, Bolton and Bury Canal, which connect to the River Irwell.
Developer Scarborough International Properties has enlisted Chinese company BCEG for the construction of phase 1 of its 24.5 acre development in Manchester.
This comprises of 571 homes and associated commercial space that will be completed in October 2018. The first residents are expected to start moving in to the apartments in March 2018.
Middlewood Locks will deliver a new mixed-use neighbourhood with 2,215 new homes and 900,000 sq ft of commercial space including offices, hotel, shops, restaurants, a convenience store and gym.
Paul Kelly, Development Director of Scarborough, said: “We are delighted to have secured planning permission for the second phase of Middlewood Locks.
“This is the result of a huge amount of hard work on the part of Salford City Council and our development team to create the best possible scheme.
“We can now look forward to delivering a substantial number of new homes and jobs to the region and help secure the wider generation of Salford and Greater Manchester.”