The preferred option will see the A548 upgraded, with a new road linking the A55 and A548 just after the Flintshire Bridge.
It forms part of over £650m of Welsh Government infrastructure improvements in North Wales, with Deeside in particular benefiting from Welsh Government investment.
Economy and Infrastructure Secretary Ken Skates said: “I’m delighted to announce the red route as my preferred option to address the congestion problem in the Deeside Corridor, A55/A494/A548, area.
“The next steps will be to develop a preliminary design, which considers the environmental and engineering issues in more detail and looks to address some of the issues raised during the consultation.”
The Economy Secretary also announced he would be progressing the delivery of the A494 River Dee Bridge Improvement scheme to investigate options to resolve the existing traffic bottleneck and overcome issues with the existing bridge.