Standing nearly 140m high, the giant observation wheel – dubbed The Whey Aye in celebration of its location – will be 5m taller than the London Eye.
Hong Kong-based developer, The World Wheel Company, said the project will see up to £100m invested in the city.
Designed by architect Concept I, the wheel and associated buildings will be a destination food and drink experience for Newcastle called The Giant’s Quay.
Cllr Ged Bell, Newcastle City Council’s cabinet member for employment and investment, said: “The idea of one of the world’s biggest observational wheels operating here in Newcastle has captured a lot of people’s imaginations.
“The development has the potential to be a real game-changer, creating hundreds of jobs for local residents and attracting thousands of new visitors, which can only be good for shops, restaurants, cafes and local businesses.
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The development will also include a 12m human-shaped steel statue, a food hall, and a virtual golf club.
“I am delighted that planning committee have approved these exciting plans. They have listened to all of today’s speakers, and I look forward to seeing this derelict site coming back to life over the coming months.”