Two passengers and a passer-by where also injured when part of the building collapsed on Kingsway near to Holborn station.
The London Fire Brigade said: “A woman has died this evening after concrete masonry from a building collapsed onto a car she was driving on Kingsway near to Holborn underground station.
“Firefighters released a man and a woman from the vehicle but sadly the woman was pronounced dead at the scene.
“The man, who was sitting in the back of the car, was taken to hospital.
“Another woman, also travelling in the rear of the car, managed to get out of the vehicle before the Brigade arrived and she was also taken to hospital. Around ten people were evacuated from nearby buildings as a precaution.”