Landowner YP Real Estate plans three office buildings and a 200-flat block to be privately rented. There is also the potential for a new hotel.
The site was sold in early 2014 and the buildings, which housed the offices and the print works of the Yorkshire Post, have now been demolished to clear a five acre development site.
Sheppard Robson are architects for the scheme with Buro Happold as Engineers.
Paul Fox, of Fox Lloyd Jones, acting as agents for the landowners, said: “Our design team has worked collaboratively with a dedicated team from Leeds City Council for a number of months to evolve the scheme.
“We believe the site will become a high profile landmark development which will dramatically announce arrival into Leeds City Centre.”
Tim Waring of Quod planning consultants, said: “The scheme is a major piece of urban regeneration in the city, and will further the local economy whilst helping to meet the housing needs of Leeds in a highly sustainable location”.