The 20t crane owned by hirer Emerson Crane Hire was heading north on the M11 between junctions five and six on Friday morning.
An overtaking coach is understood to have come into contact causing it to overturn. The driver walked away unscathed while five passengers on the coach were not seriously injured.
One lane closed due to a diesel spill, but just two hours later, four cars collided as they passed the scene of the first accident.
Two women were treated for head and neck injuries.