Brent Council has approved plans by HUB and Bridges Ventures to transform a disused office block into twin residential towers containing 239 homes.
The 21 and 26 storey towers have been designed by Maccreanor Lavington Architects and will be the tallest in Wembley.
HUB has a pipeline of more than 1,200 homes across London including the futuristic Hoola London scheme in Royal Docks.
The Chesterfield House scheme in Wembley will include a range of one, two and three-bed apartments spread across the two towers.
A lower-level plinth creates a C-shape allowing a new public space to be provided off Park Lane, right in the heart of Wembley.
Steve Sanham, Development Director at HUB Residential, said: “We’re delighted the council has supported our bid to regenerate the centre of Wembley.
“Councillors have recognised the value of well-considered design, while ensuring the local community benefits from a range of amenities.
“Above all, the capital needs more mid-market homes accessible to Londoners. HUB’s mission has always been to cater for this silent majority and we’re delighted that Wembley will join our stable of projects across the city.
“Our aim is help drive new investment into Wembley while also providing vital new housing that’s within reach of people living in the local area.
“With a community centre, new public realm and a blend of rented and for sale housing, we see a genuine community emerging at Chesterfield House.”
A spokesperson for London Borough of Brent said: “The buildings, although tall, are appropriate in this area given that it is one of our key growth areas.”