It is the first of several new projects planned at the Park in Littlemore where the college hopes to build an extra 300,000 sq ft over the next five to seven years.
The first of these speculative build projects is a 61,500 sq ft office with a roof terrace, designed by Bogle Architects.
The Plot 12 building will rise to four storeys and be built to be rated at least BREEAM Very Good.
Piers Scrimshaw-Wright, managing director, The Oxford Science Park said: “The Oxford Science Park was established 25 years ago as a business community to support discovery, innovation and entrepreneurship.
“With Plot 12 we have an opportunity to build the next logical and natural expansion to the Park.
“Our proposal is to speculatively build efficient and flexible, energy efficient accommodation that supports high value business growth and the local economy.”