The 50-acre brownfield site is being developed by Network Rail and St Modwen.
Earthmoving contractors are already on site and once building work has started the site is expected to sustain around 100 construction jobs each year.
Located near Derby County FC’s Pride Park stadium , the scheme will consist of 780,000 sq ft of offices, warehouses and industrial space as well as a pub, restaurant and car showroom.
Outline planning consent for the scheme is subject to the completion of a Section 106 agreement and Section 278 agreement which are expected to be finalised by the end of August.
Once received, site clearance work is anticipated to start in late 2017, with occupation of the first new commercial spaces expected at the beginning 2019.
Outline planning permission will coincide with the start of the A52 Wyvern Transport Improvement Scheme carried out by the City Council, which will further improve links and access to the site and is expected to be completed within 18 months.
St Modwen, itself, is contributing £2.7m so access roads leading to Derby Triangle can be built off Wyvern Way – at the Stanier Way and Pullman Road junctions.
Peter Rudd, Development Director at St. Modwen, said: “This is a major milestone for the progression of our joint venture with Network Rail and comes following detailed discussions with the City Council since 2014.