The Newhams Yard scheme will be built at 151-157 Tower Bridge Road and consist of three buildings of up to 10 storeys with retail, restaurants on the ground floor.
The newly-consented plans provide for 86 luxury apartments, alongside 143 aparthotel residences.
The first phase of apartments is due to be completed next summer.
David Galman, sales director at Galliard Homes said: “The scheme will create a new communal hub for the local area with a variety of cafes, restaurants and retail opportunities which we anticipate will be very popular with local residents.”