The design by architect Foster for a 510,000 sq ft building has been split into four elements and raised by up to 18m above ground level on big steel columns and braces.
Known as Colechurch House, the office-led, mixed-use scheme will stand in the shadow of the Shard near London Bridge Station and will also provide a theatre, shops, restaurant, bar, and gym.
Mace has been signed up as construction consultant by real estate investor CIT, which is acting as development manager on the project.
If planning is approved by Southwark Council, the plan is to start construction as early as spring/summer next year with the aim of completing the project by 2024.
During construction around 420 construction jobs will be sustained.