The Secklow Gate site on Avebury Boulevard close to the centre of the town, will be developed to deliver 329 PRS flats, across four buildings varying up to 11 storeys in height.
In addition, the building incorporates flexible commercial space dedicated car parking spaces.
Bill Hocking, chief executive of Galliford Try, said: “Our business is building an enviable track record in the PRS sector, and is a key sector for us as we deliver on our sustainable growth strategy.
“We look forward to creating a high-quality scheme for Milton Keynes that adds to that fantastic portfolio.”