The £100m scheme will see a mixture of affordable homes and homes for private sale built across two sites.
A design team led by Karakusevic Carson Architects has drawn up the plans, which will see 250 homes delivered on land east of Cecil Avenue, which had previously been the site of Copland School.
Opposite this site at Ujima House, another 54 homes will be built, along with workspace units, including a roadside café.
The new development will also house commercial units and community floorspace at street level.
A total of 152 homes will be made available for private sale on the Cecil Avenue site. The other 152 properties on both Cecil Avenue and Ujima House will be a mixture of affordable homes for council tenants and people on middle incomes.
Designated and partly funded by the Mayor of London, the Wembley Housing Zone aims to create new homes and jobs, new leisure, retail and workspaces, public realm improvements and increased accessibility for pedestrians, cyclists and road users.
Nick Williams, regional managing director of Wates Residential, said: “We will be working with the local community to deliver these mixed-tenure homes. This means employing the services of local businesses and people along the way to help regenerate the area and inspire a new community.”
The new development agreement represents another collaboration between Brent Council and Wates.
Both are currently working together to create 99 council homes at Church End. They have also recently delivered 149 homes at Knowles House and Anansi House.