Jason Windsor, chief financial officer, will formally leave on 1 September to become chief financial officer at investment giant abrdn plc.
Persimmon chief executive Dean Finch will then assume interim responsibility for the finance function, supported by Mike Smith, group financial controller.
The board said it would now start the hunt for a new finance chief.
Roger Devlin, chairman, said: “On behalf of the board, I would like to thank Jason for the contribution he has made supporting Persimmon’s drive to build a strong and sustainable business, providing good quality homes for families across the country.”