Kingsley Thornton, currently director at £150m turnover Domis takes over his role with immediate effect.
McCarren, aged 54, set up Domis in 2017 after leaving now defunct building contractor Forrest where he was then chief executive.
To date, Domis has delivered over 5,000 new homes across dozens of schemes mainly in the North West.
McCarren said: “It has been a huge honour to serve as managing director of Domis for seven years and I am incredibly proud of what we have achieved as a team in that time.
“The time is, however, now right for me to think about life beyond Domis and enjoy what comes next for me and my family.
“The business couldn’t be in a better position and I am delighted to hand over the reins to Kingsley under whose stewardship I am certain Domis will continue to build inspiring new schemes and delight clients across the UK.”
Thornton said: “Now as managing director of Domis, I am looking forward to taking the business forward into a new phase, building on the success Lee and I enjoyed together as we deliver more high-quality schemes in places around the UK where new homes are in shortest supply and highest demand.”
Simon Ismail, managing director of Salboy, added: “Together with Fred Done, Salboy’s founder and biggest supporter, I want to thank Lee McCarren for the enormous contribution he has made not only to the Domis business but to the skylines of Manchester, Salford and many other cities across the UK.”