Developer Humber Tech Park said the ambitious plan would create one of the largest AI data centre campuses in Europe and represented an opportunity to secure a £2.2bn to £3bn investment in the area.
The plan includes three large buildings, offices and a 300,000 sq ft horticultural glass house with possible district heating system.
A new electricity substation would be built on the site to help handle the 386MW of IT system power requirements, the planning application said.
If the whole project were built out over a three to four-year period, the project would be supporting at least 2,500 to 3,500 jobs a year on and off site.