The start on site this month follows the success of 6 Wellington Place, which was fully let within four weeks of practical completion earlier this year.
The five-floor office job is understood to be worth more than £25m for a building that is designed to achieve an Excellent BREEAM rating.
Once completed at the end of 2017, the full Wellington Place scheme will boast a total of 1.5m sq ft of commercial, retail, leisure and residential space.
The landmark Wellington Place development is funded by a joint venture between Hermes Investment Management and CPPIB, a professional investment management organisation that invests on behalf of 19 million Canada Pension Plan contributors and beneficiaries.
James Dipple, Chief Executive of MEPC, said: “It’s great to see the regeneration of this large masterplanned site coming together.
“Fuelled by strong demand from local, national and international companies, Wellington Place is coming out of the ground at an impressive pace.”