Four fire engines were called to deal with the blaze on the westbound carriageway between J21 Milnrow and J20 Rochdale.
Greater Manchester Fire Service said: “The vehicle was well alight on arrival of crew and the heat had caused the vehicles tyres to explode which could be heard across parts of Rochdale and Oldham.”
The road reopened on Monday morning but one lane was still closed while a clean-up operation and removal of wreckage continued.