The Talbot Mill in Castlefield will be turned into 200 flats in a £50m scheme put together by the specialist warehouse redevelopment firm.
Designed by ShedKM, the 1750,000 sq ft scheme will see the historic textile mill on Ellesmere Street and a shared courtyard area transformed.
Tim Heatley, co-founder of Capital & Centric, said: “Talbot is a stunning example of Manchester’s industrial heritage – something the city is quite rightly proud of. Our plans build on the structure’s inherent beauty and create a neighbourhood centred on a shared courtyard garden.
“The essence of a building is in its original features. Our first priority with all our projects is to keep what we can. It’s an essential part of honouring the stories of the thousands of people who’ve passed through Talbot’s doors across the decades.
“We’ve worked with talented designers to make sure the new and old sit well together.”