Developer Prosperity Capital Partners aims to transform the site opposite the Manchester Arena into a new city centre district dubbed New Brewery Gardens.
Designed by architect Assael, the plans include five brick-clad towers ranging between 26 and 12 storeys on the site, which is presently used as a car park.
The development will be split between 181 flats for private market sale in the largest tower and 375 build to rent flats in the four remaining blocks arranged around an internal landscaped courtyard.
Wardell Armstrong as structural and civil engineering consultant and Hilson Moran as M&E, sustainability and fire engineering consultant.