The firm said it had struck a funding deal and work would now start this summer on the £35m project, subject to coronavirus restrictions being lifted.
When finished the Adair Street hotel will be acquired and occupied by the Fattal Group and operate under Fattal’s Leonardo Hotel brand.
The 110,000 sq ft hotel will span 14 floors with a Jenga-inspired profile designed by Stephenson Studio.
Durham-based J H Partners is the M&E consultant with Bury-based Booth King Partnership providing structural design.
Tim Heatley co-founder of Capital & Centric said: “In these difficult times it’s even more important to be pushing ahead with our Adair Street hotel.
“It’s going to be a striking new addition to Manchester’s skyline and an anchor development in the Piccadilly East neighbourhood.
“With residents due to move into our Crusader and Phoenix developments later this year and plans for other homes in the area this is going to be a thriving new part of the city.
“We’re also creating a new public square flanked by a cafe bar, providing some much needed outside space that anyone can enjoy.
“Yes, everyone’s been hit by the shock of Coronavirus, and we’ve recently set up our building opposite the Mackie Mayor as an emergency supplies depot. Manchester will bounce back and these deals are a positive reminder of how resilient our city region is.”