The 1.13 hectare site will contain 245 new homes which are expected to complete in early 2023.
Tower Works is being delivered by Richardson and Ask Real Estate in conjunction with Homes England and with funding from Legal & General.
Ben Holmes, Real Estate director at Richardson said: “We are pleased to be on site and looking forward to making swift progress in delivering these superb new homes and at the same time writing the next chapter in the history of Tower Works.
“The site’s three landmark towers, Giotto, Verona and Little Chimney are very much part of the Leeds skyline and they form a unique focal point for the scheme, being pretty much the first thing you see as you enter the city by train.
“Richardson and Ask are really proud to be regenerating this great location and in doing so creating new homes and public open spaces, delivering a bright new future for these superb Grade II listed structures.”
Mark Gibson, managing director at Sir Robert McAlpine for UK North, said: “It is great to see this superb historic site move forward to deliver much needed housing for the Leeds city centre.
“We are already involved in the regeneration of the South Bank area of the city centre so moving forward with Tower Works means we will be able to continue to provide jobs for the skilled local workforce.”
The delivery team also includes: project managers and QS Faithful and Gould; Structural and civil engineer, Renaissance; landscape architect, Oobe and engineering firm WSP.