The plans will see the abandoned grade-II Great Grimsby Ice Factory, which was built in 1900 to provide crushed ice for the town’s trawlers, redeveloped into offices and a conference centre.
Plans for a 160-bed hotel next door were also approved.
London-based developer and entrepreneur Tom Shutes is behind the scheme, which has been designed by architect Waugh Thistleton, to act as a catalyst for the wider regeneration of Grimsby Docks.
The professional team includes M&E consultant Cundall and structural engineer Watermans.