The scheme in Bordesley Green will deliver more than 546 homes and 710 student rooms across four blocks on a current brownfield site.
This will include the development of a landmark tower of up to 37-storeys in height.
New outdoor courtyards and public open spaces will also be delivered, creating an attractive new space for the whole community.
As part of the transformation the locally listed Myona building (pictured above), which has historic links to Jacobs Biscuits, will be retained and restored.
Paul Squire, chief executive at Sama Investments, said: “Garrison Circus will transform an underutilised brownfield site to unlock a new gateway into Digbeth, while also supporting the wider regeneration of the area.
“Not only will we deliver much-needed new homes and support the vibrancy of nearby universities, but our plans offer street-level community uses and green space for existing residents in the area to enjoy.
“We’ve worked closely with Birmingham City Council and other partners to ensure this exciting project delivers true value for the area.
“We look forward to continuing our progress with the city and our partners to deliver Garrison Circus – and the wider regeneration of Digbeth – over the coming years, driving local growth, and creating hundreds of jobs in the process.”