In Birmingham, Vistry has sealed the deal to deliver the regeneration of City Hospital after working closely with Birmingham City Council and Sandwell and West Birmingham Hospitals NHS Trust.
The Homes England-owned site has outline planning permission for 750 homes, of which more than 50% will be affordable or private rent tenures, with the remaining homes for open market sale.
The site will also have more than 8,000 sq ft reserved for commercial and community space.
A second partnership deal in Hardingstone, Northamptonshire, will see the Vistry deliver 250 mixed-tenure homes with more than 50% presold.
The site is also formerly owned by Homes England and has outline planning permission.
The majority of the 1,000 new homes will be manufactured off-site using timber frames from the Vistry Works East Midlands factory in Leicestershire.
Greg Fitzgerald, chief executive of Vistry, said: “These deals further evidence the benefit of our long-term strategic partnership with Homes England, enabling the group to deliver a significant number of mixed tenure homes in the Midlands.
“Furthermore, the unique capabilities of Vistry Works will allow us to utilise timber frame manufacturing at scale across both sites, speeding up housing delivery whilst reducing carbon emissions.”