The £45m programme of capital projects will predominantly take place at the and the Royal Victoria Infirmary sites.
Projects include theatre and ward refurbishment programmes, clinical improvements, public facing refurbishments and critical infrastructure/backlog maintenance upgrades.
Neil Kennedy, commercial director, Robertson Construction North East, said: “This is an exciting opportunity to develop a long-term partnership with The Newcastle upon Tyne Hospitals NHS Foundation Trust and contribute to the enhancement of healthcare infrastructure in the North East.”