Construction work at the Rochdale Road site on the edge of Manchester’s Northern Quarter is expected to start in September.
The 229-bedroom Premier Inn hotel will be set over 10 storeys with an integrated restaurant, bar, and check-in area on the ground floor.
Whitbread acquired the site from Premcor in February 2024 as part of the company’s ongoing strategy of investing in strategic locations across Manchester.
Rochdale Road is the latest investment by Premier Inn owner Whitbread in Central Manchester in recent years.
Anthony Judge, Regional director for GMI Construction, said: “Following on from GMI and Whitbread’s collaboration in delivery of the nationally recognised and impressive Premier Inn development in Keswick, its brilliant to see our partnership go from strength to strength.
“This latest development in the iconic Northern Quarter of Manchester will be a striking new addition to the skyline with its remarkable brickwork façade. We are delighted to be a part of this major project and greatly look forward to progressing with this scheme.”