The first phase starts with a £3m enabling works contract for the £60m project to transform 10 acres of brownfield land off Robert Hall Street and West Park Street.
Countryside Partnerships will deliver the main building project once it has received full planning approval.
The collaboration will see the delivery of 137 homes and 137 apartments, 40% of which will be affordable and managed by the council’s local housing company, Derive.
All of these homes will be designed to meet the “Salford Standard” which exceeds the Future Homes Standard.
There will be improvements to existing public open space and the creation of new public parks.
Joe Turner, managing director, Vistry Manchester and Cheshire East, said: “We are delighted to deliver this new development for Salford Council.
“It will provide a significant number of affordable homes, whilst bringing a previously redundant brownfield site back into beneficial use, which is exactly what we seek to achieve as an organisation.”