The decision by Olympic Delivery Authority’s Planning Committee is the culmination of three years of intensive planning work.
It means that the Legacy Corporation is on course to develop its first neighbourhood Chobham Manor after the Games finish, with the first family homes set to be ready at the end of 2014.
Barratt, Taylor Wimpey and Countryside Properties are presently battling it out for this 800-home village.
The plans are expected to create 2,500 construction jobs during the course of the build.
The Legacy Communities Scheme covers 158 acres of the 558 acre Queen Elizabeth Olympic Park with up to 6,800 homes planned across five neighbourhoods.
They will serve new and existing residents of East London with new schools, nurseries, community spaces and health centres.
The plans also set out more than half of the 8,000 permanent jobs which are anticipated to be created on the Park over a 20 year period, from when it begins to reopen in July, 2013.
Andrew Altman, Chief Executive of the London Legacy Development Corporation, said:
“This decision represents a giant step forward for east London’s future and the culmination of years of hard work with the local communities and Olympic host boroughs.
“We can now realise the vision of creating a new piece of the city that will transform people’s lives with new opportunities.”
Around 40% of the homes are family homes with the majority of the neighbourhoods drawing inspiration from London’s heritage of terraced housing.
Up to 35% will be affordable housing in line with the London Plan.
There will be a rich public realm typical of what can be found in London’s great neighbourhoods, including 29 play spaces, plazas, canal paths, roof gardens and cycle paths.
Three new schools, two primary schools and a secondary school, will support the neighbourhoods and the surrounding area along with Chobham Academy school, which sits just next to the Olympic Village and will open in September 2013.