Work will start in early February on the new facility at Knowle West, which will be the first building in the south west to achieve a BREEAM outstanding environmental and sustainability standard.
Designed by architect Stride Treglown, it will provide 40,000 sq ft of workshop and office space, and is expected to support 350 jobs.
The development forms part of wider plans to regenerate Filwood Park, which is being led by the Homes and Communities Agency and also includes a provision for new public park and up to 150 new and affordable homes.
The £12m project, funded by Bristol City Council, has received £5.37m from the European Regional Development Fund.
Mayor of Bristol George Ferguson said: “This is a really important development for South Bristol as well as being a flagship green building for the city delivered during 2015 when Bristol is European Green Capital.”
Derek Quinn, Executive Director, Midas Construction said: “This is also particularly good news for local employment and sub-contractors in the area.”