The council has granted planning permission for the 320,000 sq ft development located at the junction of Bishop’s Bridge Road and the Grand Union Canal, with the new London Underground Hammersmith & City line station to the south.
The scheme will include 15 storeys of high-quality office space with the retail and office entrance at canal level.
Ian Lindsay, Crossrail Land and Property Director said: “Securing planning permission for this major new commercial development is an important step forwards in the continued transformation of Paddington.
“Crossrail is the first UK rail project to integrate new and improved rail infrastructure with high-quality over-site development and public realm improvements.
“This development will be a huge boost to regeneration in the area and a further phase in the renaissance of Paddington as a major commercial location.”
Crossrail current over-station schemes and partners:
Grosvenor Estates (Bond Street West – 65 Davies Street)
Great Portland Estates (Bond Street East – 18/19 Hanover Square)
Derwent London (Tottenham Ct Rd East – Astoria Site/Goslett Yard)
Cardinal Lysander Group (Farringdon West – Cardinal House)
Aviva Investors (Liverpool Street West – 101 Moorgate)
Berkeley Homes (Woolwich Station)